Aims: Basic medical science course is the first stage of medical education. Evaluation of comprehensive examinations is an index of assessing the performance quality of universities, students and educational departments. This study was carried out with the aim of determining the comprehensive medical basic science examination results and its related factors in a five-year period.

  Methods: This descriptive-analytical study was carried out on 153 medical students of one of the medical universities of Tehran city participating in the comprehensive basic medical science examination during 2004-08, who were selected by census sampling method. The data collection tools were the questionnaire and checklist of demographic data and student and educational factors. Data was analyzed by Student T -test, Chi-square test and variance analysis using SPSS 12 software .

  Results: The mean and standard deviation of students’ diploma average score, basic medical science course average score and the comprehensive basic medical science examination score in the five-year period were 15.17 and 1.39, 14.93 and 1.50 and 118.34 and 19.95, respectively, while the national average score was 121.3 at the same period. The mean score of the studied university was above national average in September 2005, September 2006, February 2007 and February 2008.

  Conclusion: The mean score shows an increasing trend on the whole, but decreases since 2006.