Aims: The students’ academic achievements are noticed by the managers of academic centers.  One of the major factors in the academic achievements is academic enthusiasm. The aim of this study was to predict the academic enthusiasm based on spiritual intelligence and psychological tenacity in the students of Birjand University of Medical Sciences. 

Instrument & Methods: In the correlational cross-section study, 165 students of Birjand University of Medical Sciences were studied in 2015-16 academic year. The subjects were selected based on Morgan table and via stratified random sampling method. Data was collected using spiritual intelligence, Ahvaz psychological tenacity, and academic enthusiasm scales. Data was analyzed by SPSS 22 software using Pearson correlational coefficient, synchronic regression, and independent T test. 

Findings: There were positive and significant correlations between academic enthusiasm and spiritual intelligence (r=0.10) and psychological tenacity (r=0.21; p<0.01). 0.16 of academic enthusiasm variance were predicted by spiritual intelligence and psychological tenacity, mutually. Of the components of spiritual intelligence, existential critical thinking and transcendental consciousness could predict academic enthusiasm, only. 

Conclusion: Academic enthusiasm can be predicted based on spiritual intelligence and psychological tenacity.