Introduction: Today, the use of appropriate training strategies that are compatible with the principles of the brain are considered in science education. Because of the greater compatibility of the contextual learning strategy with the principles of the brain based learning, this study examined the impact of this strategy on natural Science education.
Methods: The research method is semi experimental. The statistical population includes all third grade elementary students in Tabriz studying in 1397-1398. Using multi-stage cluster sampling method, 112 students (57 in the experimental group and 55 in the control group) were selected as the sample. The The measuring tool includes a test of learning at two levels of knowledge and the level of understanding and higher levels, which was performed in the pre-test and post-test. The educational plan in the experimental group was implemented by trained teachers in 8 sessions. While, the control group was trained with the conventional approach. Covariance test was used to analyze the data.
 Result: The results show that the level of learning at the level of knowledge between the studied samples in the experimental group before (mean 4.45) and after the intervention (mean 5.89) was not statistically significant (p = 0.326). However, at the level of understanding and higher, the amount of learning before (5.35) and after the intervention (10.80) is a significant difference (p = 0.001).
 Conclusion: Applying a contextual strategy that is more consistent with brain-based principles can be used as an appropriate approach to improve learning level in natural science education.
Key Word: brain-based education principle, contextual strategies, level of learning, natural science education.